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URGENT: Questions about diarrhoea

VivienOblivion

New Born Pup
Joined
Feb 18, 2023
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Location
The Netherlands
Hi everyone!

First of all, Merry Christmas 😊

On Wednesday last week, I noticed that my guinea pig Bebita (6 years old female) had been doing half-sneezes occasionally, accompanied by some weight loss and a little bit of blood found in one of her nostrils. I took her to the vet, and according to her, it was a "superficial nasal infection". It didn't spread to/derive from the lungs. Bebita was prescribed Doxycycline (0.8 ml, twice a day) for 8 days. Bebita was also already on 5 kg Metacam (twice a day) prior to this for her arthritis. Starting from Friday, 2 days after she began her antibiotic treatment, she began to have acute diarrhoea. I know that this is probably because we didn't give her any probiotic. This was because my vet, who is usually quite cavy savvy, told us that the use of probiotics is optional. She also strongly discouraged the use of commercial probiotics like Benebac/Fibreplex/Zoolac Propaste, and said we could use poop soup if we really want to. We were then told to continue the use of Metacam, but to lower the dose to 4 kg (twice a day). As a result of this information, we decided that it was better not to administer yet another (and this one supposedly optional) substance into her, on top of the whole concoction already. She also has been taking Thiamacare (0.15 ml, twice a day) everyday for the past year for her hyperthyroidism 😞

I really regret not giving it anyway. The consistency of her poop ranges from watery cream to moist Play-Doh. The poops are not formed at all, and they smear all over the dog training pee mats we have to replace frequently in her enclosure. Furthermore, she farts a lot and seems to frequently strain while going, squeaking in pain or out of discomfort. Besides that, she still seems alert, eats a little bit of hay by herself, still has an appetite for vegetables, walks around occasionally, etc. Basically, she didn't seem "extremely" ill aside from the diarrhoea. But she is definitely less active than she usually is, which is especially noticeable because she has hyperthyroidism.

After the discovery on Friday, I started to follow all the recommended procedures on this forum & other sources. These include removing fresh vegetables/fruits, increasing fibre intake, maintaining hydration, syringe feeding her Oxbow Critical Care/Selective Recovery+/mashed up high-fibre pallets/wheat powder with water, etc., giving poop soup from a healthy companion. We also read that it was good to stop with the antibiotic that is causing issues, or else the piggy might die very quickly. However, this is also a highly debated subject it seems, because a lot of people also recommend continuing with the antibiotics, despite the adverse effects, in order to remove the infection thoroughly.

On Saturday, I went to one of the only vets that was open, for a consultation. They had only very basic knowledge of guinea pigs, and absolutely no medicine or information that could help me in that moment. Bebita's symptoms continued, with no significant improvement. On Sunday evening, I went to the emergency vet hospital, which has an exotic pets' section, for a consultation. This visit was a bit more helpful. The vet told me that Bebita does not seem like an animal who was dying, and she still seemed alert and had some appetite. He then put a fresh sample of her poop under the microscope, which apparently had a large amount of yeast. This suggests Candidiasis and gut imbalance, probably indeed developed as a result of the use of Doxycycline and Metacam. I had suspected as much, so it all seemed to make sense. Her situation & symptoms do seem to match those of Candidiasis. He injected subcutaneous fluid under her skin to keep her hydrated. She was then prescribed Nystatin (0.65 ml, twice a day) and Cisaral Drops (0.4 ml, twice a day) for a week. I immediately questioned this of course, because providing gut stimulant in the case of diarrhoea seems odd, even potentially dangerous, to me. He explained that it does indeed seem counterintuitive, but Cisapride can potentially help with normalising gut mobility, and diarrhoea is still a form of irregular gut movement.

Her diarrhoea still hasn't improved much since Friday, but her condition does seem stable. I am still freaking out though, because you never know when it will suddenly take a downturn...it is frustrating and saddening that her diarrhoea just won't seem to go away or improve. Hearing her squeak in pain/discomfort while passing and having her feet and bum covered in her own faeces (despite the constant cleaning) breaks my heart...😓😓
I am currently waiting for the Fibreplex to be delivered, but it is a long wait because of Christmas of course. No vets or pet stores in the Netherlands carry Fibreplex because most of them don't even know what it is, and otherwise discourage the use of it. The vet from the emergency vet hospital even strongly advised against poop soup, because he suggests that to do this safely requires confirming the health status of the source guinea pig more accurately and thoroughly to prevent the spread of other diseases/bacteria.

Below are some questions I have about her condition:
1. Could it ever be helpful to use Cisapride for diarrhoea? Does anyone here have any experience with this?
2. Is it normal for diarrhoea to still be present after almost 5 days (from Candidiasis)?
3. How soon should I see an improvement with her diarrhoea while using Nystatin, on top of all the other measures that are already taken?
4. All the vets I have spoken to advise against taking guinea pigs off vegetables even while they suffer from diarrhoea, because especially during an illness, they need their nutrients. A lot of these nutrients come from vegetables, and it would be difficult to solely rely on syringe feeding to meet all of these needs. I know that this is the complete opposite of what many other sources, including this forum, advise. So what would be the right thing to do in Bebita's situation?
5. How long (approximately) does it take to see an effect from the use of poop soup as a probiotic to return the gut balance after the use of antibiotics?

I would really really appreciate any information you can provide that could potentially help Bebita with her speedy recovery ❤️
Thank you in advance!
 
Hi everyone!

First of all, Merry Christmas 😊

On Wednesday last week, I noticed that my guinea pig Bebita (6 years old female) had been doing half-sneezes occasionally, accompanied by some weight loss and a little bit of blood found in one of her nostrils. I took her to the vet, and according to her, it was a "superficial nasal infection". It didn't spread to/derive from the lungs. Bebita was prescribed Doxycycline (0.8 ml, twice a day) for 8 days. Bebita was also already on 5 kg Metacam (twice a day) prior to this for her arthritis. Starting from Friday, 2 days after she began her antibiotic treatment, she began to have acute diarrhoea. I know that this is probably because we didn't give her any probiotic. This was because my vet, who is usually quite cavy savvy, told us that the use of probiotics is optional. She also strongly discouraged the use of commercial probiotics like Benebac/Fibreplex/Zoolac Propaste, and said we could use poop soup if we really want to. We were then told to continue the use of Metacam, but to lower the dose to 4 kg (twice a day). As a result of this information, we decided that it was better not to administer yet another (and this one supposedly optional) substance into her, on top of the whole concoction already. She also has been taking Thiamacare (0.15 ml, twice a day) everyday for the past year for her hyperthyroidism 😞

I really regret not giving it anyway. The consistency of her poop ranges from watery cream to moist Play-Doh. The poops are not formed at all, and they smear all over the dog training pee mats we have to replace frequently in her enclosure. Furthermore, she farts a lot and seems to frequently strain while going, squeaking in pain or out of discomfort. Besides that, she still seems alert, eats a little bit of hay by herself, still has an appetite for vegetables, walks around occasionally, etc. Basically, she didn't seem "extremely" ill aside from the diarrhoea. But she is definitely less active than she usually is, which is especially noticeable because she has hyperthyroidism.

After the discovery on Friday, I started to follow all the recommended procedures on this forum & other sources. These include removing fresh vegetables/fruits, increasing fibre intake, maintaining hydration, syringe feeding her Oxbow Critical Care/Selective Recovery+/mashed up high-fibre pallets/wheat powder with water, etc., giving poop soup from a healthy companion. We also read that it was good to stop with the antibiotic that is causing issues, or else the piggy might die very quickly. However, this is also a highly debated subject it seems, because a lot of people also recommend continuing with the antibiotics, despite the adverse effects, in order to remove the infection thoroughly.

On Saturday, I went to one of the only vets that was open, for a consultation. They had only very basic knowledge of guinea pigs, and absolutely no medicine or information that could help me in that moment. Bebita's symptoms continued, with no significant improvement. On Sunday evening, I went to the emergency vet hospital, which has an exotic pets' section, for a consultation. This visit was a bit more helpful. The vet told me that Bebita does not seem like an animal who was dying, and she still seemed alert and had some appetite. He then put a fresh sample of her poop under the microscope, which apparently had a large amount of yeast. This suggests Candidiasis and gut imbalance, probably indeed developed as a result of the use of Doxycycline and Metacam. I had suspected as much, so it all seemed to make sense. Her situation & symptoms do seem to match those of Candidiasis. He injected subcutaneous fluid under her skin to keep her hydrated. She was then prescribed Nystatin (0.65 ml, twice a day) and Cisaral Drops (0.4 ml, twice a day) for a week. I immediately questioned this of course, because providing gut stimulant in the case of diarrhoea seems odd, even potentially dangerous, to me. He explained that it does indeed seem counterintuitive, but Cisapride can potentially help with normalising gut mobility, and diarrhoea is still a form of irregular gut movement.

Her diarrhoea still hasn't improved much since Friday, but her condition does seem stable. I am still freaking out though, because you never know when it will suddenly take a downturn...it is frustrating and saddening that her diarrhoea just won't seem to go away or improve. Hearing her squeak in pain/discomfort while passing and having her feet and bum covered in her own faeces (despite the constant cleaning) breaks my heart...😓😓
I am currently waiting for the Fibreplex to be delivered, but it is a long wait because of Christmas of course. No vets or pet stores in the Netherlands carry Fibreplex because most of them don't even know what it is, and otherwise discourage the use of it. The vet from the emergency vet hospital even strongly advised against poop soup, because he suggests that to do this safely requires confirming the health status of the source guinea pig more accurately and thoroughly to prevent the spread of other diseases/bacteria.

Below are some questions I have about her condition:
1. Could it ever be helpful to use Cisapride for diarrhoea? Does anyone here have any experience with this?
2. Is it normal for diarrhoea to still be present after almost 5 days (from Candidiasis)?
3. How soon should I see an improvement with her diarrhoea while using Nystatin, on top of all the other measures that are already taken?
4. All the vets I have spoken to advise against taking guinea pigs off vegetables even while they suffer from diarrhoea, because especially during an illness, they need their nutrients. A lot of these nutrients come from vegetables, and it would be difficult to solely rely on syringe feeding to meet all of these needs. I know that this is the complete opposite of what many other sources, including this forum, advise. So what would be the right thing to do in Bebita's situation?
5. How long (approximately) does it take to see an effect from the use of poop soup as a probiotic to return the gut balance after the use of antibiotics?

I would really really appreciate any information you can provide that could potentially help Bebita with her speedy recovery ❤️
Thank you in advance!

Hi and welcome

Doxycycline is unfortunately one of the antibiotics that can really impact on the digestive gut bacteria and upset them badly, allowing potentially other things to overgrow (candida is fungal). It can take a long time for the gut microbiome to recover. The guinea pig digesive tract is very sensitive once overset and what you can do sadly rather limited since oral steroids are total no no for all rodents. :(

Please keep in mind that over 75% of what a guinea pigs eats in a day and what both the digestive system and the dental growth rate are laid out for is highly nutritious grass fibre which is broken down in two runs through the gut.
Pellets, veg and any treats all together only replace the supplementary role of wild forage and should all together only make 20-25% of the daily food intake. Any syringe feeding support is there to replace the all important hay/grass fibre intake.

Not Eating, Weight Loss And The Importance Of Syringe Feeding Fibre
All About Syringe Feeding and Medicating Guinea Pigs with Videos and Pictures

You could try an enhanced probiotic like bene bac plus or (UK brand) fibreplex to help the gut to normalise.
Probiotics Live Gut Microbiome Transfer ('Poo Soup'); Recovery Formula Foods And Vitamin C: Overview With Product Links and Transfer Recipe

Whether you want to continue with veg or not is your own decision. Candidiasis is a fungal overgrowth and not dysbiosis (overgrowth of 'bad' digestive bacteria that is usually at the bottom of the common bloat and diarrhea).

Since I do not have personal experience with candidiasis, I cannot answer your question but I would give it 1-2 weeks time.
 
My situation was a little different, but one of my piggies recently had an overgrowth of yeast after a course of antibiotics as well. He did not suffer from diarrhoea though, but rather bloat and was a little congested from time to time. But regarding the time to see improvement: he was also prescribed nystatin for the yeast problem, and it really did take the whole 10 day course he was prescribed for him to return to his normal self, with major improvements only after 7 days of nystatin. If Bebita is also still getting antibiotics I can imagine it would take a little longer since those will keep upsetting the balance in her gut.

Maybe your usual vet is open again between Christmas and New Year’s, so you can call them for advice or reassurance about how soon you should see improvement, since they know your piggy? I hope Bebita is feeling better soon!
 
My situation was a little different, but one of my piggies recently had an overgrowth of yeast after a course of antibiotics as well. He did not suffer from diarrhoea though, but rather bloat and was a little congested from time to time. But regarding the time to see improvement: he was also prescribed nystatin for the yeast problem, and it really did take the whole 10 day course he was prescribed for him to return to his normal self, with major improvements only after 7 days of nystatin. If Bebita is also still getting antibiotics I can imagine it would take a little longer since those will keep upsetting the balance in her gut.

Maybe your usual vet is open again between Christmas and New Year’s, so you can call them for advice or reassurance about how soon you should see improvement, since they know your piggy? I hope Bebita is feeling better soon

Hello Apples! Thank you for your response, it is really helpful 😊 I’m sorry to hear that your piggy went through bloat and congestion, that must have been tough too :/ I recently lost a piggy to sudden, acute bloat and her last moments were terrible to witness…you mentioned that you only saw major improvements after 7 days, but did you also see any gradual improvements before that point? I stopped with her antibiotic treatment after 2 days, so it’s been almost a week now. She started with her Nystatin treatment last Sunday, and still no improvement now. If anything, her appetite and energy level seem to have decreased even more and her coat looks a bit rough. Did your piggy have the same thing when she was on Nystatin? :(
 
My situation was a little different, but one of my piggies recently had an overgrowth of yeast after a course of antibiotics as well. He did not suffer from diarrhoea though, but rather bloat and was a little congested from time to time. But regarding the time to see improvement: he was also prescribed nystatin for the yeast problem, and it really did take the whole 10 day course he was prescribed for him to return to his normal self, with major improvements only after 7 days of nystatin. If Bebita is also still getting antibiotics I can imagine it would take a little longer since those will keep upsetting the balance in her gut.

Maybe your usual vet is open again between Christmas and New Year’s, so you can call them for advice or reassurance about how soon you should see improvement, since they know your piggy? I hope Bebita is feeling better soon!
Hello Apples! Thank you for your response, it is really helpful 😊 I’m sorry to hear that your piggy went through bloat and congestion, that must have been tough too :/ I recently lost a piggy to sudden, acute bloat and her last moments were terrible to witness…you mentioned that you only saw major improvements after 7 days, but did you also see any gradual improvements before that point? I stopped with her antibiotic treatment after 2 days, so it’s been almost a week now. She started with her Nystatin treatment last Sunday, and still no improvement now. If anything, her appetite and energy level seem to have decreased even more and her coat looks a bit rough. Did your piggy have the same thing when she was on Nystatin? :(
 
Hi and welcome

Doxycycline is unfortunately one of the antibiotics that can really impact on the digestive gut bacteria and upset them badly, allowing potentially other things to overgrow (candida is fungal). It can take a long time for the gut microbiome to recover. The guinea pig digesive tract is very sensitive once overset and what you can do sadly rather limited since oral steroids are total no no for all rodents. :(

Please keep in mind that over 75% of what a guinea pigs eats in a day and what both the digestive system and the dental growth rate are laid out for is highly nutritious grass fibre which is broken down in two runs through the gut.
Pellets, veg and any treats all together only replace the supplementary role of wild forage and should all together only make 20-25% of the daily food intake. Any syringe feeding support is there to replace the all important hay/grass fibre intake.

Not Eating, Weight Loss And The Importance Of Syringe Feeding Fibre
All About Syringe Feeding and Medicating Guinea Pigs with Videos and Pictures

You could try an enhanced probiotic like bene bac plus or (UK brand) fibreplex to help the gut to normalise.
Probiotics Live Gut Microbiome Transfer ('Poo Soup'); Recovery Formula Foods And Vitamin C: Overview With Product Links and Transfer Recipe

Whether you want to continue with veg or not is your own decision. Candidiasis is a fungal overgrowth and not dysbiosis (overgrowth of 'bad' digestive bacteria that is usually at the bottom of the common bloat and diarrhea).

Since I do not have personal experience with candidiasis, I cannot answer your question but I would give it 1-2 weeks time.
Hi Wiebke,

Thank you for your response and your useful information :) didn't know Doxycycline was so harsh for them, otherwise I would have asked for another antibiotic or sure :( I want to give her gut microbiome some time to recover, since she's already on medication that will hopefully help...but I fear that she is suffering too much from the none-stop diarrhoea. Her butthole also seems to protrude more than usual, suggesting some kind of swelling perhaps. I just wish there was more I could do for her right now besides wait.
I'm also struggling with knowing how often I should give her a bum bath, because she is dirty again during even the drying. Baths can be pretty stressful for guinea pigs of course, so I don't want to give it too much. I'm also struggling with knowing how often I should give her a bum bath, because she is dirty again during even the drying. Baths can be pretty stressful for guinea pigs of course, so I don't want to give it too much.

I have read that diarrhoea is also a common symptom of Candidiasis right? And how long does it usually take to see some improvement for gut imbalance if we use both Fibreplex and poop soup?

For now I will keep syringe feeding her like you suggested, and provide vegetables sparingly if at all, avoiding especially the watery ones like lettuce and cucumber (very sad because she loves these especially) :(
 
Hi Wiebke,

Thank you for your response and your useful information :) didn't know Doxycycline was so harsh for them, otherwise I would have asked for another antibiotic or sure :( I want to give her gut microbiome some time to recover, since she's already on medication that will hopefully help...but I fear that she is suffering too much from the none-stop diarrhoea. Her butthole also seems to protrude more than usual, suggesting some kind of swelling perhaps. I just wish there was more I could do for her right now besides wait.
I'm also struggling with knowing how often I should give her a bum bath, because she is dirty again during even the drying. Baths can be pretty stressful for guinea pigs of course, so I don't want to give it too much. I'm also struggling with knowing how often I should give her a bum bath, because she is dirty again during even the drying. Baths can be pretty stressful for guinea pigs of course, so I don't want to give it too much.

I have read that diarrhoea is also a common symptom of Candidiasis right? And how long does it usually take to see some improvement for gut imbalance if we use both Fibreplex and poop soup?

For now I will keep syringe feeding her like you suggested, and provide vegetables sparingly if at all, avoiding especially the watery ones like lettuce and cucumber (very sad because she loves these especially) :(

Hi

Just give her a gentle wipe with baby warm water once or twice daily. ;)
Ask your vet for flamazine cream for the sore outside parts.

It will still take some time; fibreplex and poo soup can support the gut but not necessarily heal.

None of us likes to see our beloved ones unwell. Nor do we like feeling rather helpless. Please makse sure that your girl still gets enough fluid.
 
My situation was a little different, but one of my piggies recently had an overgrowth of yeast after a course of antibiotics as well. He did not suffer from diarrhoea though, but rather bloat and was a little congested from time to time. But regarding the time to see improvement: he was also prescribed nystatin for the yeast problem, and it really did take the whole 10 day course he was prescribed for him to return to his normal self, with major improvements only after 7 days of nystatin. If Bebita is also still getting antibiotics I can imagine it would take a little longer since those will keep upsetting the balance in her gut.

Maybe your usual vet is open again between Christmas and New Year’s, so you can call them for advice or reassurance about how soon you should see improvement, since they know your piggy? I hope Bebita is feeling better soon!
Also, I phoned my usual vet today. I'm going to bring her in tomorrow for an appointment, but they're not really sure what they could do for her right now. They are also confused about why there are no improvements at all. But like you and Wiebke said, it can take awhile. I'll have to try to be patient ><
 
Hi

Just give her a gentle wipe with baby warm water once or twice daily. ;)
Ask your vet for flamazine cream for the sore outside parts.

It will still take some time; fibreplex and poo soup can support the gut but not necessarily heal.

None of us likes to see our beloved ones unwell. Nor do we like feeling rather helpless. Please makse sure that your girl still gets enough fluid.
Hi @Wiebke,

I will follow your advice with the baby warm water to clean her, thank you 😊

I understand. I will try to be patient. I am just scared that maybe her body will give up...
Is there a possibility that her guts will not heal and will never return to normal? :(

You're right, both things are awful...she still drinks a lot of water by herself but I'm not sure if it's enough.
 
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