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Not wanting to be picked up is normal. Most piggies will never want to be caught with bare hands as it is akin to being eaten. Definitely don’t chase them
The best way to pick them up is by herding the into a box or carrier and then picking them up from there.
It is important you do this even if they don’t like it, as they need to be weighed once a week as part of routine care. Weight checks are the only way to ensure they are eating enough hay, and weight loss can sometimes be the first sign of a brewing illness
I have four piggies, two of whom are 6 years old (the other two are 18 months) and they still don’t like being picked up. I do handle them every week for their weight and health checks and nail clipping but I don’t handle them just for cuddles as they don’t like it. Instead I sit on the floor with them and they come to interact with me on their terms.
The guide below explains more.
How To Pick Up And Weigh Your Guinea Pigs Safely (videos)