Not really sure what you mean, do you mean a cardboard box or plastic box? As long as it doesnt have a lid and was big enough then you probably could, although if its cardboard and they wee the bottom would get a bit soggy!
as long as it is not closed and isn't a cardboard one on carpet you should be ok but it'd need to be pretty big for a playpen. if your using a smaller one for cleaning out time then that would be fine if it was only for a few mins!
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