It looks like you’ve found your guinea pigs grease gland. Many people are confused by this when they first get guinea pigs so you’re not the only one! It is a small gland on the lower back that produces scent (I may be wrong though), it can get a little crusty though (especially in boars).
Cleaning is not often needed, only if it is very crusty or becomes infected. It can be done with a damp cloth and warm water, though if there are large flakes they may be able to be very carefully removed with a fingernail.
The anus and genitals are in the same area (sort of), but under the guinea pig.
Guinea pigs should be given a basic weekly health check and weighing. This should start at the nose and work backwards to the anus/genitals and grease gland. Including ears, eyes, teeth, lips, skin, coat, feet, claws, lymph node areas (dewlap, behind the front legs, in-front of the hind legs), nipples, grease gland, anus and genitals. As well as allowing you to observe any developing health issues, doing this weekly health check will familiarise you with the anatomy of your guinea pig, meaning you will know when something looks unusual and could signify an illness.
They should ideally be weighed once per week, just place them on normal kitchen scales (directly on them or in a bowl) and record the weight of each pig each week. If you guinea pig becomes unwell you will often see wright loss before you see any obvious symptoms so it can be treated before it gets any worse.