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Guinea Pig Breathing and Sneezing Issues

Animas

New Born Pup
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We have already been to the vet and are continuing to work with this vet, I'm looking for advice to see if anyone else might have ideas that can help in case our vet might have missed or overlooked something.
Nina is sow a little over 4 years old.
We have a second guinea pig kiki, also a 4 year old sow who has shown none of the same symptoms and has appeared completely normal through all of this.
These piggies have a 4 foot by 8 foot fleece lined enclosure, inside they also have smaller cages with aspen shavings (that have since been switched to carefresh fluffy bedding)

Our guinea pig nina had some minor sneezing and discharge from one eye for a couple months. It appeared to start getting worse fast with some significant lethargy so we took her to the vet ASAP. Vet started antibiotics (doxycycline/Baytril) with nebublized albuterol/gentamycin/saline. There was some initial improvement which makes us think she did have an infection when we took her in, but she quickly plateaued (even while continuing to give the antibiotic does as prescribed) and still has sneezing and breathing issues. We are currently at 2 weeks of the 3 week antibiotic regimen with little improvement past the first couple days.

Her current issues do appear intermittent. Sometimes she will look mostly normal and other times she sounds like she has a stuffy nose and is breathing harder than normal with her belly clearly moving more than her usual breathing.

After not seeing a ton of improvement, we went back to the vet. They did xrays and ultra sound and do not see signs of pneumonia or heart problems. The vet also suggested we move from aspen to something else so we have started using care fresh fluffy bedding over aspen shavings. The vet also gave a subcutaneous dose of the steroid prednisone. After this visit she appeared to look pretty good for the following 24 hours so we think the steroid may have helped, but we're not sure because her issues are intermittent.

After letting the vet know about the potential positive effect from the steroid the vet prescribed meloxicam as an NSAID to see if reducing inflammation could help. We have started this medication today but its too soon to see if it has had any effect.

Anyone see anything we - or the vet - might have missed? Anything else we should try?
 
Hi and welcome

Please check whether a bowl of steaming water next to the cage is bringing relief. If it does, then please consider humidifying regularly. Dry winter air (as well as dry air from air conditioning) can make some piggies react more strongly.

Otherwise please check your hay ('dust extracted' can be a rather elastic term) and see whether a different brand might do better; check for household irritants listed in the guide link below: Irritants to Avoid Around Guinea Pigs

In winter, I would also check for monodioxide (gas) if your home is at potential risk. Piggies are more sensitive to it.

Please note that if the problem is indeed an environmental factor, changes may take a while to filter through and may not necessarily be instant.

All the best!
 
Thanks for the tips Wiebke,

ill try some humidification soon, our humidity has been all over the place and recently its pretty low (~40% RH) any targets I should aim for?

Hay is a very good thought I hadnt considered. We currently use Oxbow Timothy hay. It looks like I could get some Orchard Grass hay that we could try as a substitute.
For other irritants, no smoke/purfume/aersols used. We have used scented candles but in other rooms of the house. I'll stop our use for a while and see if it helps.

Monodioxide - did you mean carbon monoxide or is this something I havent heard of? For carbon monoxide we have detectors that are reading 0PPM in the house so while a good idea, I dont think this is our issue.

Very helpful places to start!
Thanks!
 
I have happy news to update this time. We talked to our Vet and changed up medicines:
Stopped all previous treatments.
Added the following treatments:
Azithromycin 1x per day
Nebulized Collodial Silver 2-3x per day
Nebulized Hypertonic saline 1x per day
Maropitant (also known as Cerenia) given as a drop into a nostril 2x per day
Hand feeding critical care from oxbow in case she isnt eating enough.

Our piggy has basically complete recovered over the course of a few days!
I did end up getting orchard grass hay and completely replacing our timothy hay. It didnt seem to have any result and I cautiously reintroduced timothy hay in one area and didnt see any negative side effects so they are getting both timothy and orchard grass hay now.
 
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