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antibiotic advice

dee10535

New Born Pup
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Hello, my guinea pig (about 4 years or so) has windpipe thickening, possibly inflammation (that's what the X-ray suggests to the vet). Originally, they said it could be bronchitis, although today they said she probably also has some extent of nasal congestion that's not super obvious externally. The only symptom she noticeably has is loud, wheezy kind of breathing. Either way, they're treating for possible URI, although they did say it could be something else, like allergic bronchitis. Anyway, I first noticed the breathing issue on Monday night, and brought her in on Tuesday. She had her first dose of enrofloxacin on Tuesday at noon. She is on a 10-day course of the enrofloxacin with 0.09 ml twice a day, so fairly small dose. She is also receiving an anti-inflammatory, meloxicam, 0.18 ml once a day. It is the end of Day 3, and the vets had said we should see improvement within 2-3 days. But now that it's the end of Day 3, she is no better or worse. Breathing/possible congestion not improved at all. I brought her in today, and they didn't hear anything in her lungs to suggest it's progressed. They said I had two options: stay the course or add doxycycline. I decided to take the doxycycline, and am considering starting tomorrow. The thing is she did warn me the risk of side effects goes up with this double combo, and since she hasn't had any yet I hate to have to add on something new. The dose for the doxycycline is 0.1 ml twice a day, so not too bad dose-wise but ultimately she will be getting twice as much antibiotic into her system. I did request a probiotic, and they obliged (only once a day though, not twice so can't do it before each dose). They did say though that there is no real evidence that the probiotic is useful, it's all anecdotal. Anyway, we are leaving for an extended trip (a week or so) on Monday, and we plan to leave both my guinea pigs in the care of a sitter. Unless she backs out in which case I'll be forced to take them with us in a cage. I know there is a chance she might have to take one of them to the vet (my other guinea pig isn't symptomatic yet but if it is infectious, I am expecting her to get it. They were exposed to each other for enough time that I thought the stress of separating them would do more harm than good.) But I would like to minimize the risks of the sitter having to do this, so am nervous to start the doxycycline on top of the Baytril with potential serious effects.

Does anyone have any suggestions on the best course of action to take? Should I stick with the Baytril only for a couple more days, and then tack on doxycycline the day I leave if there's still no improvement? Or would it be better to just start the doxycycline tomorrow anyway, and take the risk? The vet said that in her experience, 25% to 33% of guinea pigs show side effects (she didn't say whether it was diarrhea, loss of appetite, or something else) with this specific combo. She also didn't seem to imply that one way was better than the other, but based on everything I've seen, she should have been improving by now, which makes me think the Baytril is either ineffective or too weak (or maybe it's not an infection, who knows?)
 
Hi, unfortunately it is up to you to make the call...I know for me personally using the Baytril my piggy improved after about 5 days...however he would go downhill again pretty much as soon as he came off it...also for us the probiotic was useful as it helped his stomach stay calm while taking his meds...I'm not sure about your set up for the piggies but to make sure its not allergies for them...use fleece and bath mats as their bedding (i pair it with puppy pads as the absorbant layer) and try getting long stemmed hay (just checking the bags for the longer stems rather than shorter parts) and shaking the hay put before it is given so the majority of the dust is at the bottom and isn't used...also keeping their immediate area clean (i use sensitive skin baby wipes to wipe down bars and the floors near cages but Diluted Milton fluid is good too) this should hopefully mitigate if it is allergies...as for me it helped my piggies...also using steam can help if theyre congested...just keeping the bowl where it cant be touched or knocked by them while the steam can still circulate...make sure you have critical care in just incase they lose their appetite...and spacing doses out can help aswell...hopefully no matter what you choose your piggy will get better...
 
Hello, my guinea pig (about 4 years or so) has windpipe thickening, possibly inflammation (that's what the X-ray suggests to the vet). Originally, they said it could be bronchitis, although today they said she probably also has some extent of nasal congestion that's not super obvious externally. The only symptom she noticeably has is loud, wheezy kind of breathing. Either way, they're treating for possible URI, although they did say it could be something else, like allergic bronchitis. Anyway, I first noticed the breathing issue on Monday night, and brought her in on Tuesday. She had her first dose of enrofloxacin on Tuesday at noon. She is on a 10-day course of the enrofloxacin with 0.09 ml twice a day, so fairly small dose. She is also receiving an anti-inflammatory, meloxicam, 0.18 ml once a day. It is the end of Day 3, and the vets had said we should see improvement within 2-3 days. But now that it's the end of Day 3, she is no better or worse. Breathing/possible congestion not improved at all. I brought her in today, and they didn't hear anything in her lungs to suggest it's progressed. They said I had two options: stay the course or add doxycycline. I decided to take the doxycycline, and am considering starting tomorrow. The thing is she did warn me the risk of side effects goes up with this double combo, and since she hasn't had any yet I hate to have to add on something new. The dose for the doxycycline is 0.1 ml twice a day, so not too bad dose-wise but ultimately she will be getting twice as much antibiotic into her system. I did request a probiotic, and they obliged (only once a day though, not twice so can't do it before each dose). They did say though that there is no real evidence that the probiotic is useful, it's all anecdotal. Anyway, we are leaving for an extended trip (a week or so) on Monday, and we plan to leave both my guinea pigs in the care of a sitter. Unless she backs out in which case I'll be forced to take them with us in a cage. I know there is a chance she might have to take one of them to the vet (my other guinea pig isn't symptomatic yet but if it is infectious, I am expecting her to get it. They were exposed to each other for enough time that I thought the stress of separating them would do more harm than good.) But I would like to minimize the risks of the sitter having to do this, so am nervous to start the doxycycline on top of the Baytril with potential serious effects.

Does anyone have any suggestions on the best course of action to take? Should I stick with the Baytril only for a couple more days, and then tack on doxycycline the day I leave if there's still no improvement? Or would it be better to just start the doxycycline tomorrow anyway, and take the risk? The vet said that in her experience, 25% to 33% of guinea pigs show side effects (she didn't say whether it was diarrhea, loss of appetite, or something else) with this specific combo. She also didn't seem to imply that one way was better than the other, but based on everything I've seen, she should have been improving by now, which makes me think the Baytril is either ineffective or too weak (or maybe it's not an infection, who knows?)
Hi, the baytril dose you describe sounds rather low to be honest, 0.4mls or 0.5mls is more usual- but baytril isnt always effective for respiratory infections anyway.
Doxycycline is more effective for certain stubborn respiratory complaints like chlamydia which in piggies is a fairly common culprit for persistent respiratory infections/pneumonia- we have been prescribed doxycycline before for Blodwen who had chlamydia pneumonia, and it was amazingly effective but also wiped out her gut bacteria- she stopped eating and pooping and needed probiotic and support food from a syringe. The doxycycline dose you have been prescribed sounds fine, but is usually only once daily, or twice daily for the first 2 or 3 days then once a day after that. So maybe have some fibreplex and critical care/SS recovery plus to hand just in case digestive support is needed while taking doxycycline.
Antibiotics may take up to a week to clear an infection enough to observe a noticeable improvement, so please be patient! In the meantime the vet could prescribe bisolvon decongestant which gives great symptom relief alongside antibiotics and loxicom. Nebulising may also be something to discuss with the vet.
Best of luck, hope piggy improves x
 
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